Provide harm reduction services for people who use drugs. National HIV strategies, policies and programmes in both concentrated and generalized epidemics should meet the needs of people who use drugs. A comprehensive package of services should be provided that – in addition to tailored HIV prevention, treatment and care interventions – includes: needle and syringe programmes; opioid substitution therapy and other drug-dependence treatment; prevention and treatment of sexually transmitted infections; condom programming; diagnosis and treatment of viral hepatitis and tuberculosis; and structural interventions to improve access to services.